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June 8, 2026Open Access

Telomeric heterochromatin acts in trans to promote meiotic centromere assembly via Aurora B kinase recruitment

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Authors

HHHaitong HouJiangnan UniversityAMAna López MoralesUniversity of Colorado Anschutz Medical CampusLYLiu YWannan Medical College

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Overview

Mechanistic study reveals telomeric heterochromatin transfers proteins to reassemble meiotic centromeres via Aurora B kinase, highlighting a safeguarding pathway for chromosome segregation.

Key Points

  • To determine how cells maintain centromere identity and reassemble dismantled kinetochores to prevent missegregation during meiosis.
  • Tracked the localization and transfer of the telomeric heterochromatin component Swi6/HP1 to pericentromeric regions during meiosis.
  • Assessed Haspin kinase-mediated histone H3 phosphorylation, chromosomal passenger complex recruitment, and Aurora B target phosphorylation.
  • Engineered phosphomimetic mutants of CenpA and CenpC to test sufficiency for centromere reassembly in meiotic and mitotic cells.
  • The telomere bouquet transfers Swi6/HP1 to pericentromeres, driving Haspin kinase-dependent histone H3 phosphorylation and recruitment of the Aurora B-containing chromosomal passenger complex.
  • Aurora B directly phosphorylates core centromeric proteins CenpA and CenpC to trigger kinetochore reassembly, which phosphomimetic mutants of CenpA or CenpC bypass.
  • The Aurora B-driven centromere restoration pathway is conserved during centromere dismantling in mitotically proliferating cells.

Cite This Study

Hou et al. (2026) studied this question.

synapsesocial.com/papers/6aa602f050dab972bddd5b2bhttps://doi.org/10.64898/2026.06.06.730608
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression2025
  2. 2Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression2024 · 1 citations
  3. 3CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation2024
  4. 4Aurora B and Aurora C pools at two chromosomal regions collaboratively maintain chromosome alignment and prevent aneuploidy at the second meiotic division in mammalian oocytes2024 · 3 citations
  5. 5Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex2024