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October 23, 2025Nature CommunicationsOpen Access

Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression

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Authors

KVKruno VukušićITIva M. Tolić

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Overview

Our findings demonstrate Aurora kinases regulate chromosome congression through a negative feedback mechanism and impact molecular motor activity.

Key Points

  • Chromosome congression is regulated by Aurora kinases and their activity alters molecular motor function, affecting timing and stability.
  • Inhibition of Aurora A kinase disrupts the regulation of microtubule attachments at kinetochores, enabling congression initiation.
  • The study highlights a negative feedback mechanism involving Aurora kinases, providing insights into kinetochore–microtubule attachment regulation.
  • Findings suggest the importance of Aurora activity gradients for the precise control of chromosome movement during cell division.

Cite This Study

Vukušić et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f7421e2https://doi.org/10.1038/s41467-025-64804-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression2024 · 1 citations
  2. 2Telomeric heterochromatin acts in trans to promote meiotic centromere assembly via Aurora B kinase recruitment2026
  3. 3CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation2024
  4. 4KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C2025
  5. 5Kinesin‐7 <scp>CENP</scp>‐E mediates centrosome organization and spindle assembly to regulate chromosome alignment and genome stability2024