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November 1, 2025Cell ReportsOpen Access

KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C

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Authors

JMJiahang MiaoHMHara MasatoshiKSKuan-Chung Su

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Overview

Genome-wide screen shows KIF18A impacts chromosome congression in CENP-C mutants, highlighting synthetic lethality and biomarkers.

Key Points

  • To elucidate the role of KIF18A in chromosome congression and its interaction with CENP-E and CENP-C.
  • Performed a genome-wide Cas9-based functional genetics screen
  • Used a hypomorphic CENP-C mutant to analyze kinetochore interactions
  • Assessed synthetic lethality with KIF18A knockout in CENP-C mutant
  • Identified KIF18A as essential for chromosome alignment during early prometaphase
  • Knockout of KIF18A led to synthetic lethality in CENP-C mutants
  • Reduced function of CENP-E was linked to the synthetic defect in CENP-C mutants

Cite This Study

Miao et al. (2025) studied this question.

synapsesocial.com/papers/6925435ec0ce034ddc357f50https://doi.org/10.1016/j.celrep.2025.116515
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional genetics with a hypomorphic CENP-C mutant reveals a regulatory system for chromosome congression2025 · 1 citations
  2. 2Kinesin‐7 <scp>CENP</scp>‐E mediates centrosome organization and spindle assembly to regulate chromosome alignment and genome stability2024
  3. 3Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression2025
  4. 4Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression2024 · 1 citations
  5. 5Chromosome alignment relies on spindle-localized control of Cdk1 activity2024