Key result
Cytomorphology combined with clinical data and immunocytochemistry accurately suggests the primary malignancy site in effusions.
Key points are not available for this paper at this time.
Design
Review
May support primary site inference in effusion cytology; leaves open prospective validation before practice change.
Metastatic carcinomas to the pleura, pericardium, or peritoneum may be the first manifestation of an underlying malignancy. In those instances, the presumed primary site may be accurately suggested based on the cytomorphologic features of the malignant cells in the effusion, along with clinical data and ancillary studies (most commonly immunocytochemistry).
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Filie et al. (2006) studied this question. Cytomorphologic features of malignant cells in effusions, combined with clinical data and immunocytochemistry, can accurately suggest the primary site of an underlying malignancy.
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