What question did this study set out to answer?

To determine whether perinatal HIV infection alters gray matter volume organization and structural covariance brain networks in adolescents.

January 15, 2018Scientific ReportsOpen Access

Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents

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Authors

JLJielan LiLiaoning Normal University LGLei GaoXinjiang Medical University ZWZhi WenWuhan University

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Implication

Neuroimaging study finds altered gray matter volume and shifted network hubs in vertically HIV-infected adolescents, indicating distinct neurodevelopmental disruption.

Key Points

To determine whether perinatal HIV infection alters gray matter volume organization and structural covariance brain networks in adolescents.
Analyzed structural MRI scans from 25 vertically HIV-infected adolescents and 33 HIV-exposed-uninfected control participants.
Reconstructed gray matter covariance networks and calculated regional gray matter volumes using the GAT toolbox.
Assessed associations between regional gray matter volume alterations, Mini-Mental State Examination scores, and CD4 cell counts.
Gray matter volume was significantly reduced in the anterior cingulate cortex, right pallidum, right occipital lobe, inferior parietal lobe, and bilateral cerebellum crus.
Global network metrics did not differ significantly between groups, but nodal alterations were marked in frontal, temporal, basal ganglia, and cerebellar regions, accompanied by an increased number and spatial shift of brain hubs toward sensorimotor and temporal areas.
Decreased gray matter volume in the anterior cingulate cortex and bilateral cerebellum correlated with lower Mini-Mental State Examination scores, while CD4 counts correlated positively with volumes in the anterior cingulate cortex and sensorimotor areas.

Cite This Study

Li et al. (2018) studied this question.

synapsesocial.com/papers/6aa60a655becb0bc28eeccc5 https://doi.org/10.1038/s41598-018-19290-5

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Implication

Neuroimaging study finds altered gray matter volume and shifted network hubs in vertically HIV-infected adolescents, indicating distinct neurodevelopmental disruption.

Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents

Discussion

Member takes

Implication

Key Points

Cite This Study

Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents

Discussion

Member takes

Implication

Key Points

Cite This Study

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