What question did this study set out to answer?

To investigate the topological organization of gray matter structural covariance networks in early HIV-infected individuals and assess the impact of combination antiretroviral therapy.

September 20, 2022Frontiers in NeurologyOpen Access

Altered gray matter structural covariance networks in drug-naïve and treated early HIV-infected individuals

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Authors

RLRuili LiSouthwest Petroleum University YGYuxun GaoCapital Medical University WWWei WangNational Natural Science Foundation of China

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Implication

Cross-sectional study reveals altered structural covariance networks in early HIV-infected adults, indicating disrupted sensory transmission and compensatory frontal rewiring.

Key Points

To investigate the topological organization of gray matter structural covariance networks in early HIV-infected individuals and assess the impact of combination antiretroviral therapy.
Enrolled 65 HIV-positive adults aged 25–50 years (34 receiving combination antiretroviral therapy [cART+] and 31 medication-naïve [cART–]) alongside 35 matched healthy controls undergoing high-resolution T1-weighted MRI.
Employed a sliding-window method across age bins to construct cortical thickness-based structural covariance networks using Pearson's correlation coefficients.
Evaluated group differences across network topology metrics—including betweenness centrality, path length, modularity, small-worldness, and efficiency—using ANOVA and network-based statistics.
Both HIV+/cART+ and HIV+/cART– groups exhibited significantly reduced betweenness centrality in the parietal and occipital lobes alongside reduced nodal path length in the frontal lobe relative to controls (P < 0.05, FDR-corrected).
Compared to both healthy controls and medication-naïve individuals, HIV+/cART+ individuals demonstrated decreased modularity and small-worldness properties with increased global efficiency (P < 0.05, FDR-corrected).

Cite This Study

Li et al. (2022) studied this question.

synapsesocial.com/papers/6ab23ea9e8d68c1c7b07dd34 https://doi.org/10.3389/fneur.2022.869871

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Implication

Cross-sectional study reveals altered structural covariance networks in early HIV-infected adults, indicating disrupted sensory transmission and compensatory frontal rewiring.

Altered gray matter structural covariance networks in drug-naïve and treated early HIV-infected individuals

Discussion

Member takes

Implication

Key Points

Cite This Study

Altered gray matter structural covariance networks in drug-naïve and treated early HIV-infected individuals

Discussion

Member takes

Implication

Key Points

Cite This Study

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