Key result
Electron microscopy and special stains distinguish Ewing's sarcoma, lymphoma, and neuroblastoma despite similar light microscopy patterns.
Population
Round-cell sarcomas involving bone (Ewing's sarcoma, malignant lymphoma, and metastatic neuroblastoma)
Design
Review
Authors
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May improve differential diagnosis of histologically similar bone tumors; leaves open prospective validation of accuracy in modern cohorts.
Electron microscopy and special stains are useful for distinguishing between different types of round-cell sarcomas of bone that appear similar under routine light microscopy.
Friedman et al. (1971) conducted a review in Round-cell sarcomas of bone. Electron microscopy and special stains vs. Routine light microscopy was evaluated. Electron microscopy and special stains can distinguish between Ewing's sarcoma, malignant lymphoma, and metastatic neuroblastoma, which show similar patterns under routine light microscopy.
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