Key result
Erg channels mediate inward-rectifying K+ currents regulating cardiac repolarization, frequency adaptation, and resting potential.
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Design
Review
Describes the physiological roles of erg channels in cardiac repolarization and endocrine function.
The erg channels mediate an inward-rectifying K(+) current because of their peculiar gating kinetics. They are involved in repolarization of the cardiac action potential, frequency adaptation, and maintenance of the resting potential. Reduction of erg currents via an intracellular signal cascade underlies the thyrotropin-releasing hormone-induced increase in prolactin secretion.
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Schwarz et al. (1999) studied this question. Erg channels mediate inward-rectifying K+ currents that are involved in cardiac action potential repolarization, frequency adaptation, and maintenance of the resting potential.
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