Key result
Homologous heart transplantation in dogs alters recipient ST-T waves, suggesting release of an organ-specific substance.
Why the study?
Does homologous heart transplantation cause electrocardiographic changes in the recipient heart in a canine model?
Population
10 dogs subjected to homologous heart transplantation
Comparison
Homologous heart transplantation vs Animals treated with drugs alone or animals…
Design
Preclinical
Follow-up
Approximately one week
Authors
Loading...
Does not inform human transplant ECG monitoring; leaves open whether organ-specific substances mediate similar changes in clinical allografts.
Does homologous heart transplantation cause electrocardiographic changes in the recipient heart in a canine model?
Homologous heart transplantation in dogs induces ECG changes in the recipient heart, suggesting the release of organ-specific substances from the transplanted heart.
DePasquale et al. (1965) studied Heart transplantation (n=10). Homologous heart transplantation vs. Animals treated with drugs alone or subjected to kidney transplantation was evaluated on Electrocardiographic changes (S-T segment and T wave). Homologous heart transplantation in dogs resulted in S-T segment and T wave changes in the recipient heart approximately one week post-transplantation, suggesting the release of an organ-specific substance.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: