What is the clinical evidence from this study?

Study design: Observational. Population: Thoracic liposarcomas (n=24). Intervention: Histologic subtype. Primary outcome: Death from disease.

What does this research mean for the field?

Clinical outcome in mediastinal liposarcoma is strongly associated with histologic subtype, with pleomorphic and myxoid subtypes demonstrating more rapid progression and higher disease-specific mortality compared to well-differentiated and dedifferentiated subtypes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 15, 2012The American Journal of Surgical Pathology

Liposarcomas of the Mediastinum and Thorax

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Key result

Liposarcoma histologic subtype is strongly linked to disease mortality, especially in pleomorphic and myxoid variants.

n=24

Population

24 patients with thoracic liposarcomas (13 men, 11 women, mean age 53 years, range 15 to 73 years)

Design

Case_series

Follow-up

mean 55 months (range 8 to 252 months)

Authors

JBJennifer M. BolandMayo Clinic TCThomas V. ColbyUniversity of Arkansas at Little Rock AFAndrew L. FolpeCardio-Oncology

Discussion

Member takes

Implication

May inform prognosis via histologic subtyping in mediastinal liposarcoma; leaves open validation in larger series.

Study Design

Type

Observational (n=24)

Structured PICO

Population

24 patients (mean age 53 years, 11 women) with confirmed thoracic liposarcomas identified over a 60-year period, with follow-up available for 19 patients (mean 55 months).

Outcome

Clinicopathologic features, molecular genetic features, and clinical outcome (death from disease)hard clinical

Mediastinal liposarcomas show a preponderance of uncommon subtypes, and correct histologic classification is strongly associated with clinical outcome.

Cite This Study

Boland et al. (2012) conducted an observational in Thoracic liposarcomas (n=24). Histologic subtype was evaluated on Death from disease. Outcome was strongly associated with histologic subtype, with death from disease occurring in 1 of 6 well-differentiated, 1 of 4 dedifferentiated, 5 of 7 pleomorphic, and 2 of 2 myxoid liposarcomas.

synapsesocial.com/papers/6aa60da089092379003a60a5 https://doi.org/10.1097/pas.0b013e3182562bc1

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Liposarcomas of the Mediastinum and Thorax

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Liposarcomas of the Mediastinum and Thorax

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider