December 1, 1979Clinical Science
Isolation of a Renal Thiol Protease that Activates Inactive Plasma Renin
Key result
Human renal thiol protease generates renin activity in suppressed plasma by releasing inactive renin.
Population
Human renal cortex and human plasma (renin-suppressed and anephric)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Suggests a biochemical pathway for renin activation; leaves open its relevance to human cardiovascular disease.
Structured PICO
P
Population
Human renal cortex and human plasma (renin-suppressed and anephric)
I
Intervention
Isolation and application of a renal thiol protease (similar to cathepsin B)
O
Outcome
Generation of renin activitysurrogate
This study identifies a renal thiol protease capable of activating inactive plasma renin, providing insight into the biochemical pathways of the renin-angiotensin system.
Cite This Study
Slater et al. (1979) studied this question. Renal thiol protease was evaluated on Generation of renin activity. A thiol protease isolated from human renal cortex generated renin activity from renin-suppressed and anephric human plasma, representing the release of inactive renin.