Key result
ANGPT2 polymorphisms and upregulated Ang2 expression are linked to higher liver cancer risk.
Why the study?
Angiopoietin-2-mediated angiogenesis plays a crucial role in vascular-rich cancers, but the genetic polymorphism and expression level of Ang2 in primary liver cancer remained unknown.
Are Ang2 expression levels and ANGPT2 genetic polymorphisms associated with primary liver cancer risk in the Southeastern Chinese Hans population?
Case-Control (n=433)
Are Ang2 expression levels and ANGPT2 genetic polymorphisms associated with primary liver cancer risk in the Southeastern Chinese Hans population?
Upregulated Ang2 levels and specific ANGPT2 polymorphisms (rs2442588 and rs11137037) are associated with increased risk and severity of primary liver cancer in the Southeastern Chinese Hans population.
Certain ANGPT2 variants associate with elevated primary liver cancer risk in Han Chinese; hypothesis-generating for susceptibility screening, requires prospective validation.
Background: Angiopoietin-2 (Ang2)-mediated angiogenesis plays a crucial role in the pathogenesis of vascular-rich cancers. However, the genetic polymorphism and expression level of Ang2 in patients with primary liver cancer remain unknown. Methods: This study included 234 primary liver cancer patients and 199 healthy controls. The expression levels of Ang2 in liver cancer tissues and plasma were determined. Peripheral blood samples were collected to test five ANGPT2 single nucleotide polymorphisms (rs2442598, rs734701, rs1823375, rs11137037, and rs12674822). Results: Plasma Ang2 levels in patients with liver cancer were upregulated compared with that in healthy controls. The upregulation of plasma Ang2 levels was significantly associated with vascular invasion, metastasis, and clinical stage. Notably, the transcription level of ANGPT2 was elevated in tumor tissues compared with para-carcinoma tissues. Individuals with the TT genotype at rs2442598 and genotype AC and AC+CC at rs11137037 had higher liver cancer risk compared with healthy controls. Conclusions: Upregulated Ang2 levels in blood plasma and cancer tissues of liver cancer patients confirm that Ang2 plays a vital role in the pathogenesis of liver cancer. ANGPT2 rs2442588 and rs11137037 are associated with liver cancer risk, thereby highlighting their role in screening individuals susceptible to liver cancer.
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Wang et al. (2023) conducted a case-control in Primary liver cancer (n=433). ANGPT2 genetic polymorphisms and Ang2 expression vs. Healthy controls was evaluated on Liver cancer risk and plasma Ang2 levels. ANGPT2 polymorphisms rs2442598 and rs11137037 were associated with higher liver cancer risk, and Ang2 expression was significantly upregulated in the plasma and tumor tissues of patients.
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