Key result
Ischemic stroke linked to altered brain FE-dALFF values correlating with Fugl-Meyer Assessment scores.
Why the study?
Previous neuroimaging studies focused mainly on static brain activity, leaving its temporal characteristics poorly understood, especially in post-stroke patients.
Does resting-state fMRI reveal altered static and dynamic characteristics of brain activity in post-stroke patients compared to healthy controls?
Case-Control (n=39)
Does resting-state fMRI reveal altered static and dynamic characteristics of brain activity in post-stroke patients compared to healthy controls?
Fuzzy entropy of dynamic ALFF (FE-dALFF) can identify stroke-induced alterations in local brain activity and correlates with motor impairment severity.
Answers are grounded in this paper and cite their sources.
Does not support routine clinical use of FE-dALFF; hypothesis-generating for stroke motor biomarkers pending prospective validation.
Objective. Previous neuroimaging studies mainly focused on static characteristics of brain activity, and little is known about its characteristics over time, especially in post-stroke (PS) patients. In this study, we aimed to investigate the static and dynamic characteristics of brain activity after stroke using functional magnetic resonance imaging (fMRI). Approach. Twenty ischemic PS patients and nineteen healthy controls (HCs) were recruited to receive a resting-state fMRI scanning. The static amplitude of low-frequency fluctuations (sALFFs) and fuzzy entropy of dynamic ALFF (FE-dALFF) were applied to identify the stroke-induced alterations. Main results. Compared with the HCs, PS patients showed significantly increased FE-dALFF values in the right angular gyrus (ANG), bilateral precuneus (PCUN), and right inferior parietal lobule (IPL) as well as significantly decreased FE-dALFF values in the right postcentral gyrus (PoCG), right dorsolateral superior frontal gyrus (SFGdor), and right precentral gyrus (PreCG). The receiver operating characteristic analyses demonstrated that FE-dALFF and sALFF possess comparable sensitivity in distinguishing PS patients from the HCs. Moreover, a significantly positive correlation was observed between the FE-dALFF values and the Fugl-Meyer Assessment (FMA) scores in the right SFGdor ( r = 0.547), right IPL ( r = 0.522), and right PCUN ( r = 0.486). Significance. This study provided insight into the stroke-induced alterations in static and dynamic characteristics of local brain activity, highlighting the potential of FE-dALFF in understanding neurophysiological mechanisms and evaluating pathological changes.
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Tian et al. (2022) conducted a case-control in Ischemic stroke (n=39). Ischemic stroke vs. Healthy controls was evaluated on Fuzzy entropy of dynamic amplitude of low-frequency fluctuations (FE-dALFF). Ischemic stroke was associated with altered FE-dALFF values in multiple brain regions compared to healthy controls, which correlated with Fugl-Meyer Assessment scores.
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