Key result
Enterovirus or rhinovirus inoculation produces highly specific antibody responses with ~3% heterotypic rises.
Why the study?
Does inoculation with specific respiratory viruses elicit specific antibody responses in human volunteers?
Does inoculation with specific respiratory viruses elicit specific antibody responses in human volunteers?
Antibody responses to specific enteroviruses and rhinoviruses in humans are largely specific to the administered virus despite biological relatedness.
Answers are grounded in this paper and cite their sources.
Supports virus-specific responses in volunteers; leaves open heterotypic immunity relevance in natural infection.
Experiments reported here were performed on the sera of thirty-three volunteers who were infected or inoculated intranasally or intramuscularly in groups of five to nine with one of two enteroviruses, namely, echovirus 11 and coxsackievirus A21 or with one of three rhinoviruses, namely, M viruses P.K. and ECHO 28, and H virus D.C. Antibody responses occurred against the virus administered, and rarely against the other viruses used. It was concluded that although these viruses are related biologically the antibody responses in the volunteers were largely specific.
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Buckland et al. (1964) studied Healthy volunteers (respiratory virus challenge) (n=33). Inoculation with respiratory viruses (enteroviruses and rhinoviruses) was evaluated on Heterotypic antibody responses. Inoculation of human volunteers with specific enteroviruses or rhinoviruses resulted in largely specific antibody responses, with heterotypic antibody rises occurring in only 3 of 104 tests.
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