Key result
Postoperative sildenafil and inhaled nitric oxide show no benefit over historical controls for early Fontan outcomes.
Why the study?
Does postoperative administration of oral sildenafil and inhaled nitric oxide improve early postoperative outcome in patients undergoing modified Fontan operation?
Cohort (n=48)
Does postoperative administration of oral sildenafil and inhaled nitric oxide improve early postoperative outcome in patients undergoing modified Fontan operation?
Postoperative administration of oral sildenafil and inhaled nitric oxide does not improve early postoperative outcomes such as ICU stay or ventilation time after the modified Fontan procedure.
Answers are grounded in this paper and cite their sources.
Does not support routine postoperative sildenafil and inhaled nitric oxide after modified Fontan; leaves open need for randomized confirmation.
Although mortality is low after the modified Fontan procedure, there is a significant percentage of patients with prolonged postoperative recovery. The objective of this study is to evaluate the usefulness of postoperative administration of oral sildenafil and inhaled nitric oxide on early postoperative outcome. A prospective interventional and comparison study with a historical cohort was conducted. Between January, 2010 and March, 2013, 16 patients received oral sildenafil during immediate modified Fontan postoperative period. Inhaled nitric oxide was also administered if the patient was kept intubated 12 hours after surgery. Early postoperative outcome was compared with a historical cohort of 32 patients on whom the modified Fontan procedure was performed between March, 2000 and December, 2009. Postoperative administration of sildenafil and nitric oxide had no influence on early postoperative outcome after the modified Fontan procedure in terms of duration of pleural effusions, mechanical ventilation time, length of stay in the ICU, and length of hospital stay.
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Mendoza et al. (2014) conducted a cohort in Modified Fontan operation (n=48). Oral sildenafil and inhaled nitric oxide vs. Historical cohort was evaluated on Early postoperative outcome (duration of pleural effusions, mechanical ventilation time, length of stay in the ICU, and length of hospital stay). Postoperative administration of oral sildenafil and inhaled nitric oxide had no influence on early postoperative outcomes after the modified Fontan procedure compared to a historical cohort.
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