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January 25, 2023ESC Heart FailureOpen Access

Cardiovascular Health Metrics and Risk of Heart Failure in a Finnish Population: A Prospective Cohort Study

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Key result

Optimal CVH scores linked to up to ~64% lower HF risk vs inadequate scores.

  • HR 0.36 (men), HR 0.52 (women)
  • 95% CI 0.26-0.49 (men), 0.31-0.89 (women)
  • P<0.01 (men), 0.02 (women)
  • n=3,210

Why the study?

The association between cardiovascular health metrics and the risk of heart failure in a Finnish population was not established.

Do optimal cardiovascular health metrics reduce the risk of incident heart failure in an aging population?

Population

2385 men and 825 women without baseline HF in Finland

Comparison

Optimal vs average vs inadequate cardiovascular health scores

Design

Prospective population-based cohort study

Follow-up

Median 27 years for men, and 18 years for women

Authors

NINzechukwu M. IsiozorUniversity of Eastern FinlandSKSetor K. KunutsorGeneral / Preventive / LipidsAVAri VoutilainenGeneral / Preventive / Lipids

Discussion

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Overview

Optimal CVH metrics were associated with lower HF risk; supports prevention emphasis but leaves causal effects open for trials.

Study Design

Type

Cohort (n=3,210)

Structured PICO

Do optimal cardiovascular health metrics reduce the risk of incident heart failure in an aging population?

P
Population
3,210 Finnish adults (2,385 men and 825 women) without baseline heart failure, followed for a median of 27 years for men and 18 years for women.
E
Exposure
Optimal cardiovascular health (CVH) scores based on American Heart Association's CVH metrics
C
Comparator
Inadequate cardiovascular health (CVH) scores
O
Outcome
Incident heart failure (HF)hard clinical

Main Result

Effect estimate: HR 0.36 (men), HR 0.52 (women) (95% CI 0.26-0.49 (men), 0.31-0.89 (women))

p-value: p=<0.01 (men), 0.02 (women)

Maintaining optimal cardiovascular health metrics is associated with a substantially lower long-term risk of developing heart failure.

Cite This Study

Isiozor et al. (2023) conducted a cohort in Heart failure (n=3,210). Optimal cardiovascular health (CVH) scores vs. Inadequate CVH scores was evaluated on Heart failure (HR 0.36 (men), HR 0.52 (women), 95% CI 0.26-0.49 (men), 0.31-0.89 (women), p=<0.01 (men), 0.02 (women)). Optimal cardiovascular health scores were associated with a lower risk of heart failure compared with inadequate scores in both men (HR 0.36; 95% CI 0.26-0.49) and women (HR 0.52; 95% CI 0.31-0.89).

synapsesocial.com/papers/6aa620b3c616a76b5feed673https://doi.org/10.1002/ehf2.14283

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1American heart association’s cardiovascular health metrics and risk of cardiovascular disease mortality among a middle-aged male Scandinavian population2019 · 27 citations
  2. 2Healthy Lifestyle and Risk of Heart Failure2016 · 77 citations
  3. 3Lifestyle Factors in Relation to Heart Failure Among Finnish Men and Women2011 · 109 citations
  4. 4High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men.1992 · 1,294 citations
  5. 5Contribution of Major Lifestyle Risk Factors for Incident Heart Failure in Older Adults2015 · 186 citations