Key result
Transvenous pericardial access proves feasible in pigs but causes hemodynamically significant effusion in ~50%.
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Feasibility in pigs encourages preclinical refinement; leaves open human safety and efficacy studies.
Mickelsen et al. (2005) studied this question. Catheter-based transvenous access to the pericardial space was evaluated on Procedural survival and complications. A catheter-based transvenous approach to access the pericardial space was feasible in 8 pigs, with 100% survival, though hemodynamically significant pericardial effusion occurred in 4 animals.
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