Key result
Upstream cis-acting elements regulate dystrophin gene expression in a cell- and developmental stage-specific manner.
Population
Muscle cells/myogenic models
Design
Review
Authors
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Hypothesis-generating for cell-specific dystrophin therapies in cardiomyopathy; leaves open clinical translation pending in vivo validation.
The dystrophin gene promoter contains muscle-specific cis-acting elements that regulate its expression in a cell- and developmental stage-specific manner.
Klamut et al. (1989) conducted a review in Duchenne Muscular Dystrophy. Functional assays and promoter sequencing demonstrate that upstream cis-acting elements regulate dystrophin gene expression in a cell- and developmental stage-specific manner.
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