Key result
Methanol and urea inhibit papain activity without conformational changes by disrupting hydrophobic interactions.
Population
Papain (EC 3.4.4.10) enzyme
Design
Preclinical
Authors
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Hypothesis-generating for protease inhibition mechanisms; does not support clinical translation or practice changes.
Methanol inhibits papain activity likely through interference with hydrophobic interactions rather than conformational changes.
Gorin et al. (1978) studied this question. Methanol and urea was evaluated on Papain activity. Methanol and urea inhibit papain activity without causing conformational changes, likely by interfering with hydrophobic interactions between the enzyme and substrates.
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