Key result
Spinal anesthesia shows no maternal or perinatal mortality benefit over general anesthesia in severe pre-eclampsia.
Why the study?
Does subarachnoid block compared to general anesthesia improve maternal and perinatal mortality in women with severe pre-eclampsia requiring Cesarean section?
Observational (n=96)
No
Does subarachnoid block compared to general anesthesia improve maternal and perinatal mortality in women with severe pre-eclampsia requiring Cesarean section?
In women with severe pre-eclampsia undergoing Cesarean section, spinal anesthesia is associated with similar maternal and perinatal mortality but significantly less birth asphyxia compared to general anesthesia.
Spinal anesthesia was associated with similar mortality in severe pre-eclampsia; leaves open whether it reduces asphyxia or warrants randomized confirmation.
OBJECTIVE: To compare the outcome of subarachnoid block (spinal anesthesia) and general anesthesia in Cesarean delivery for women with severe pre-eclampsia. METHODS: A retrospective study of women with severe pre-eclampsia requiring Cesarean section from January 2005 to June 2009 was carried out. Maternal age, parity, gestational age at delivery, booking status, Apgar scores, maternal and perinatal mortality of the sub-arachnoid block group were compared with those of general anesthesia group using χ(2), Student t-test and Fischer exact test. RESULTS: There were no significant difference between the two groups in overall maternal mortality (5.4% vs. 11.9%, P=0.5) and perinatal mortality (2.7% vs. 11.9%, P=0.15). The general anesthesia group had significantly more birth asphyxia than the spinal group (55.9% vs. 27.0%, P=0.0006). CONCLUSION: There was no significant difference in the maternal and perinatal mortality outcome of cesarean delivery between women with severe pre-eclampsia who had regional anesthesia and those that had general anesthesia. There was significantly higher proportion of birth asphyxia in babies of women who received general anesthesia.
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Ajuzieogu et al. (2011) conducted an observational in Severe pre-eclampsia (n=96). Subarachnoid block (spinal anesthesia) vs. General anesthesia was evaluated on Maternal mortality (p=0.5). Subarachnoid block (spinal anesthesia) showed no significant difference in maternal mortality (5.4% vs. 11.9%, p=0.5) or perinatal mortality compared to general anesthesia in women with severe pre-eclampsia.
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