Main Mechanisms of Therapeutic Action in Atopic Asthma in Children

Immunological disorders are clearly demonstrated in children suffering from the atopic form of bronchial asthma, namely increase in the levels of total and specific IgE and a decrease in the number of T cells. Specific hyposensitization produces, in addition to a good clinical effect, an immunomodulating action which is not restricted to the formation of blocking antibodies but is displayed also by T cell stimulation. Our studies revealed a reduction in the level of prostaglandins E and increase in the content of prostaglandins F-2 as well as a decrease in the cAMP levels in blood serum and urine in the period free of attacks; the demonstrated effect of Euphylline, Intal and Zaditen on these values confirms the expediency of introducing these agents into the therapeutic complex.