Key result
Coronary artery compliance modification (ΔCACom) following intravascular lithotripsy was an independent predictor of stent expansion in heavily calcified coronary lesions (P=0.043).
Why the study?
IVL is theorized to facilitate stent expansion by improving coronary artery compliance, but direct evidence of this theory has not yet been provided.
Does intravascular lithotripsy modify coronary artery compliance to predict stent expansion in calcified coronary lesions?
Cohort
Yes
Does intravascular lithotripsy modify coronary artery compliance to predict stent expansion in calcified coronary lesions?
p-value: p=0.043
Modification of coronary artery compliance by intravascular lithotripsy is an independent predictor of stent expansion in heavily calcified lesions.
IVL-linked compliance gain independently predicted stent expansion in calcified lesions; hypothesis-generating for compliance-guided preparation pending prospective validation.
Background: IVL) has been demonstrated to be effective in treating balloon-crossable calcified coronary lesions by inducing calcium fractures and facilitating stent expansion (SE), theoretically by improving coronary artery compliance (CACom). Direct evidence of this theory has not yet been provided. Methods: From the BENELUX-IVL prospective registry (NCT06577038) enrolling patients with calcified coronary artery lesions treated with IVL, intravascular ultrasound-guided cases were selected. CACom was calculated as the systo-diastolic change in the luminal area (ΔA), measured using intravascular ultrasound, relative to the corresponding change in aortic pressure (ΔP). Measurements were taken directly before (pre-CACom) and after (post-CACom) IVL therapy at the most calcified segment, where IVL pulses were administered. The primary end point was CACom modification (ΔCACom), defined as post-CACom - pre-CACom, with a correlation analysis between ΔCACom and new fractures as a key exploratory aim. Secondary analysis included assessing whether ΔCACom could predict SE at the minimum stent area (MSA) and the eccentricity index. Results: = .043). Conclusions: In heavily calcified coronary lesions treated with IVL, ΔCACom is an independent predictor of SE.
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Oliveri et al. (2025) conducted a cohort in Calcified coronary artery lesions. Intravascular Lithotripsy (IVL) was evaluated on Coronary artery compliance modification (ΔCACom), defined as post-CACom - pre-CACom (p=0.043). Coronary artery compliance modification (ΔCACom) following intravascular lithotripsy was an independent predictor of stent expansion in heavily calcified coronary lesions (P=0.043).
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