Key result
PEARS achieves successful implantation for genetically determined aortic root aneurysms over 10 years.
Why the study?
Does Personalised External Aortic Root Support (PEARS) provide a safe and effective alternative for treating life-threatening genetically determined aneurysms of the aortic root?
Does Personalised External Aortic Root Support (PEARS) provide a safe and effective alternative for treating life-threatening genetically determined aneurysms of the aortic root?
Personalised External Aortic Root Support (PEARS) demonstrates proof of principle and promising 10-year outcomes as an innovative surgical approach for genetically determined aortic root aneurysms.
Provides initial support for PEARS in genetic aortic aneurysms; leaves open need for controlled trials before practice change.
Personalised external aortic support was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. After putting together a research and development team, and finding a surgeon to take on the challenge to join him in this innovative approach, he was central to the manufacture of the device, custom made for his own aorta. He was the patient for the 'first in man' operation in 2004. Ten years later he is well and 45 other people have had their own personalised device implanted. In this account, the stepwise record of proof of principle, comparative quantification of the surgical and perioperative requirements, 10 years of results, and development and research plans for the future are presented.
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Treasure et al. (2015) conducted a review in Life-threatening genetically determined aneurysms of the aortic root (n=46). Personalised External Aortic Root Support (PEARS) was evaluated. Personalised External Aortic Root Support (PEARS) was successfully implanted in 46 patients with genetically determined aortic root aneurysms over a 10-year period.
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