Key result
The TMPLR observational cohort protocol investigates interactions between lifestyle, genetics, the gut microbiome, and health.
Why the study?
Lifestyle factors are associated with chronic disease development, but how they interact with each other, genetics, and the gut microbiome to influence health remains to be understood.
Cohort
Yes
This study protocol outlines a multicenter observational cohort study in Manitoba, Canada, to investigate the interactions between lifestyle, genetics, microbiome, and health outcomes.
INTRODUCTION: Lifestyle factors, such as diet, physical activity and sleep, are associated with the development of many chronic diseases. The objective of The Manitoba Personalized Lifestyle Research study is to understand how these lifestyle factors interact with each other and with other factors, such as an individual's genetics and gut microbiome, to influence health. METHODS: An observational study of adults, with extensive phenotyping by objective health and lifestyle assessments, and retrospective assessment of early life experiences, with retrospective and prospective utilisation of secondary data from administrative health records. STUDY POPULATION: ) and geography (25% from rural areas). These stratifications were selected based on Manitoba demographics. MEASUREMENTS: Lifestyle factors assessed will include dietary pattern, physical activity, cardiovascular fitness, and sleep. Factors such as medical history, socioeconomic status, alcohol and tobacco consumption, cognition, stress, anxiety, and early life experiences will also be documented. A maternal survey will be performed. Body composition and bone density will be measured by dual energy X-ray absorptiometry. Blood pressure, pulse wave velocity, and augmentation index will be measured on two consecutive days. Chronic disease risk biomarkers will be measured in blood and urine samples. DNA will be extracted for genetic analysis. A faecal sample will be collected for microbiome analysis. Participants may provide their Manitoba personal health information number to link their study data with administrative health records. ETHICS AND DISSEMINATION: Ethics approval has been obtained from the University of Manitoba Health Research Ethics Board (protocol # HS18951; 05/01/2016). Data analysis, release of results and publication of manuscripts are scheduled to start in early 2019. Additional information at www.TMPLR.ca. TRIAL REGISTRATION NUMBER: NCT03674957; Pre-results.
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MacKay et al. (2019) conducted a cohort in Chronic diseases. Lifestyle factors (diet, physical activity, sleep) was evaluated on Interactions between lifestyle factors, genetics, gut microbiome, and health. The Manitoba Personalized Lifestyle Research (TMPLR) study is a multicentre observational cohort protocol designed to investigate interactions between lifestyle, genetics, microbiome, and health.
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