Key result
The [3H]myristic-acid labeling of the 36-kD protein in Rous sarcoma virus-transformed chicken embryo fibroblasts showed a reduction of up to 45% compared to normal cells.
Population
Chicken embryo fibroblasts (CEF) (normal and Rous sarcoma virus-transformed)
Comparison
Incubation with [3H]myristic acid for 4 hours vs Normal cells vs Rous sarcoma virus-transformed…
Design
Preclinical
Authors
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Reduced myristylation of the 36-kD substrate may alter its function in transformation; leaves open mechanistic and therapeutic implications.
The 36-kD substrate of pp60 v-src is covalently linked to myristic acid, and this myristylation is reduced in transformed cells.
Sorić et al. (1985) studied this question. Rous sarcoma virus transformation vs. Normal cells was evaluated on [3H]myristic-acid labeling of the 36-kD protein. The [3H]myristic-acid labeling of the 36-kD protein in Rous sarcoma virus-transformed chicken embryo fibroblasts showed a reduction of up to 45% compared to normal cells.
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