Key result
Age >65 predicts ~185% higher 1-year mortality in Chagas ICD patients, alongside LVEF <30%.
Population
148 patients with chronic Chagas' cardiomyopathy and primary or secondary implantable cardioverter…
Design
Cohort
Follow-up
1 year (mean 12 ± 7 months)
Authors
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Age >65 and LVEF <30% flag higher-risk Chagas ICD patients for monitoring; leaves open whether risk-stratified interventions alter outcomes.
Cohort (n=148)
Yes
Hazard Ratio: 2.85 (95% CI 1.77–3.92)
p-value: p=0.03
In patients with chronic Chagas' cardiomyopathy and an ICD, age >65 years and LVEF <30% are independent predictors of 1-year all-cause mortality.
Toro et al. (2011) conducted a cohort in Chronic Chagas' cardiomyopathy with implantable cardioverter defibrillators (n=148). Age > 65 years and LVEF < 30% vs. Age ≤ 65 years and LVEF ≥ 30% was evaluated on All-cause 1-year mortality (HR 2.85, 95% CI 1.77-3.92, p=0.03). Age >65 years (HR 2.85; 95% CI 1.77-3.92) and LVEF <30% (HR 2.68; 95% CI 1.57-3.79) were independent predictors of all-cause 1-year mortality in patients with Chagas' cardiomyopathy and an ICD.
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