Key result
Desogestrel demonstrates high contraceptive efficacy with a ~0.04 Pearl index.
Why the study?
Does a monophasic oral contraceptive containing desogestrel prevent pregnancy in women?
Does a monophasic oral contraceptive containing desogestrel prevent pregnancy in women?
Desogestrel is a highly effective oral contraceptive with a very low Pearl index of 0.04 and strong suppression of ovarian activity.
May support desogestrel for reliable contraception; leaves open broader validation beyond reviewed European studies.
Desogestrel, a new gonane progestin, has been shown to be comparable in efficacy with oral contraceptives currently in use in the United States. Results from several large efficacy studies conducted in Europe encompassing 42,640 patients in 183,212 cycles resulted in six pregnancies for a Pearl index of 0.04. This low rate, which was compared with those observed in recent U.S. clinical trials, reflects differences in study methodology. An additional indicator of an oral contraceptive's efficacy is its ability to suppress ovarian function, including follicular development and increases in plasma estradiol levels. Desogestrel has been found to be among the strongest suppressors of ovarian activity.
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Stephen L. Corson (1993) conducted a review in Contraception (n=42,640). Desogestrel vs. Oral contraceptives currently in use in the United States was evaluated on Pregnancies (Pearl index). Desogestrel demonstrated high contraceptive efficacy across several European studies, resulting in six pregnancies among 42,640 patients for a Pearl index of 0.04.
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