Key result
Desogestrel shows similar contraceptive efficacy and side-effect profiles compared to older progestogens.
Why the study?
Desogestrel is a new progestogen with low androgenic properties and potential benefits as an oral contraceptive and anti-androgen, requiring evaluation of its clinical efficacy and safety compared to older progestogens.
Is desogestrel effective and safe as an oral contraceptive compared to older progestogens?
Is desogestrel effective and safe as an oral contraceptive compared to older progestogens?
Desogestrel is an effective oral contraceptive with low androgenic properties, suitable for women with hyperandrogenic symptoms.
May support individualized choice for hyperandrogenic symptoms; leaves open need for head-to-head RCTs versus older agents.
Desogestrel is a new, potent progestogen with very low androgenic properties. When used as a contraceptive, it is a strong antiovulatory compound, even at low doses. The clinical efficacy is as good as that of the old progestogens. It has a low incidence of side effects and complications, similar to other progestogens. It may have a role as an anti-androgen in women with hyperandrogenic symptoms in need of adequate oral contraception.
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Sergio C. Stone (1995) conducted a review in Contraception and hyperandrogenic symptoms. Desogestrel vs. Older progestogens was evaluated. Desogestrel is a potent progestogen with low androgenic properties that provides clinical efficacy and side effect profiles similar to older progestogens when used as a contraceptive.
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