Key result
Microdialysis during surgical revascularization reveals marked myocardial glycerol and glutamate increases early after cardioplegic arrest.
Why the study?
Does intraoperative myocardial microdialysis provide relevant pathophysiologic information on hibernating myocardium undergoing coronary flow restoration?
Case Report (n=1)
Does intraoperative myocardial microdialysis provide relevant pathophysiologic information on hibernating myocardium undergoing coronary flow restoration?
Intraoperative myocardial microdialysis can provide real-time metabolic information during surgical revascularization of hibernating myocardium.
May inform real-time myocardial metabolism in hibernating tissue; leaves open whether microdialysis alters revascularization practice.
We present an 80-year-old woman with hibernating myocardium in the left anterior descending coronary artery (LAD) territory who underwent surgical revascularization and metabolic evaluation of the dysfunctioning segments by microdialysis (microD) technique. Myocardial lactate, pyruvate, and glucose did not show obvious changes throughout the procedure. Conversely, myocardial glycerol and glutamate concentrations markedly increased early after cardioplegic arrest and subsided after weaning from cardiopulmonary bypass (CPB) and recovery of myocardial function. Intraoperative myocardial microD may add relevant pathophysiologic information on hibernating myocardium undergoing coronary flow restoration and, eventually, improve patient care.
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Mazzoni et al. (2008) conducted a case report in Hibernating myocardium (n=1). Surgical revascularization and microdialysis was evaluated on Myocardial metabolic changes. Intraoperative myocardial microdialysis during surgical revascularization revealed marked increases in myocardial glycerol and glutamate concentrations early after cardioplegic arrest.
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