Why the study?
Do ultrastructural changes in hibernating myocardium explain the lack of response to dobutamine echocardiography despite preserved FDG uptake in patients with postischaemic left ventricular dysfunction?
Population
22 patients with postischaemic left ventricular dysfunction undergoing coronary artery bypass grafting…
Comparison
Transmural biopsy during CABG, dobutamine… vs Internal comparison between segments with…
Design
Cohort
Authors
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Greater myofibrillar loss associated with absent inotropic reserve despite FDG uptake; hypothesis-generating for ultrastructural factors in viability assessment.
Do ultrastructural changes in hibernating myocardium explain the lack of response to dobutamine echocardiography despite preserved FDG uptake in patients with postischaemic left ventricular dysfunction?
The lack of inotropic response to dobutamine in hibernating myocardium with preserved FDG uptake is driven by more severe ultrastructural damage, specifically myofibrillar loss.
Duilio Pagano (2000) studied this question.
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