Key result
Isradipine 2.5 mg twice daily lowers blood pressure by ~17/10 mm Hg at four weeks.
Why the study?
Does isradipine reduce blood pressure in patients with primary hypertension?
Does isradipine reduce blood pressure in patients with primary hypertension?
p-value: p=<0.001
Isradipine 2.5 mg twice daily is an effective and safe first-line therapy for reducing blood pressure in patients with primary hypertension.
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Supports isradipine for BP reduction in primary hypertension; leaves open first-line role pending randomized confirmation.
Lüscher et al. (1991) studied primary hypertension (n=1,647). Isradipine vs. Placebo run-in (baseline) was evaluated on blood pressure (p=<0.001). Isradipine 2.5 mg twice daily significantly decreased blood pressure from 168/102 mm Hg at baseline to 151/92 mm Hg after 4 weeks of treatment (p < 0.001).
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