What question did this study set out to answer?

To review the general clinical approach to acute poisoning and outline the principles guiding extracorporeal elimination techniques.

January 13, 2023Clinical Journal of the American Society of NephrologyOpen Access

Management of Poisonings and Intoxications

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Authors

MGMarc GhannoumUtrecht University DRDarren M. RobertsRoyal Prince Alfred Hospital

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Implication

Clinical review demonstrates acute management and extracorporeal elimination protocols in poisoned patients, highlighting hemodialysis parameters for optimal toxin clearance.

Key Points

To review the general clinical approach to acute poisoning and outline the principles guiding extracorporeal elimination techniques.
Synthesized clinical frameworks for initial resuscitation, risk assessment, gastrointestinal decontamination, and antidote delivery.
Evaluated physicochemical and pharmacokinetic properties governing extracorporeal toxin clearance.
Assessed technical parameters and operational modalities, comparing intermittent hemodialysis and continuous kidney replacement therapy.
Extracorporeal toxin clearance is highest for low-molecular-weight, water-soluble poisons exhibiting minimal protein binding (<80%), low endogenous clearance, and low volume of distribution.
Dialytic removal of antidotes such as N-acetylcysteine, ethanol, and fomepizole requires compensatory dosage increases during extracorporeal therapy.
Intermittent hemodialysis remains the preferred modality due to superior clearance efficiency, utilizing maximized blood and effluent flows with large-surface-area filters.

Cite This Study

Ghannoum et al. (2023) studied this question.

synapsesocial.com/papers/6aa658e386a9fcb249923609 https://doi.org/10.2215/cjn.0000000000000057

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Implication

Clinical review demonstrates acute management and extracorporeal elimination protocols in poisoned patients, highlighting hemodialysis parameters for optimal toxin clearance.

Management of Poisonings and Intoxications

Discussion

Member takes

Implication

Key Points

Cite This Study

Management of Poisonings and Intoxications

Discussion

Member takes

Implication

Key Points

Cite This Study

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