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The leisure intake of cannabis has shortly amplified in the past years corresponding with its decriminalization and legalization.The natural cannabis has been substituted by synthetic cannabinoids and cannabimimetic in several formulae, which are stronger.In spite of irresistible public insight into the safety of these substances, a growing quantity of grave cardiovascular adverse events are reported in sequential relation to recreational cannabis intake.A multifaceted interface between the active ingredients, the endocannabinoid system, and the autonomic nervous system is responsible in the pathophysiology.Tolerance to the properties of cannabis can develop with repetitive contact due to receptor desensitization.Effects of cannabis may be heightened or transformed by affiliated use of other illicit drugs or drug treatment indicated for the treatment of cardiovascular diseases.Nonetheless, the recent cannabis epidemic would significantly increase global burden of cardiovascular diseases
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Bhandare et al. (2020) studied this question.
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