Echocardiographic assessment of left ventricular structure and diastolic filling in elderly subjects with borderline isolated systolic hypertension (the Framingham Heart Study)
Key result
Borderline isolated systolic hypertension in the elderly links to thicker LV walls and impaired diastolic filling.
- P=0.002
- n=230
Why the study?
Does borderline isolated systolic hypertension alter left ventricular structure and diastolic filling in elderly subjects?
Population
230 elderly subjects from the Framingham Heart Study free of cardiovascular disease, including 91 with…
Comparison
Borderline isolated systolic hypertension vs Normotensive subjects (BP < 140/90 mm Hg)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Should not yet alter management of borderline isolated systolic hypertension; leaves open causal effects on ventricular remodeling.
Study Design
Type
Cross-Sectional (n=230)
Structured PICO
Does borderline isolated systolic hypertension alter left ventricular structure and diastolic filling in elderly subjects?
P
Population
230 elderly subjects from the Framingham Heart Study, including 91 with untreated borderline isolated systolic hypertension and 139 normotensive controls, free of cardiovascular disease.
E
Exposure
Borderline isolated systolic hypertension (observational exposure)
C
Comparator
Normotensive subjects (BP < 140/90 mm Hg)
O
Outcome
Left ventricular structure (M-mode values) and 6 Doppler indexes of LV diastolic fillingsurrogate
Main Result
Absolute Event Rate: 20.5% vs 19.7%
p-value: p=0.002
Elderly subjects with borderline isolated systolic hypertension exhibit increased left ventricular wall thickness and impaired diastolic filling compared to normotensive peers.
Cite This Study
Sagie et al. (1993) conducted a cross-sectional in Borderline isolated systolic hypertension (n=230). Borderline isolated systolic hypertension vs. Normotensive (BP < 140/90 mm Hg) was evaluated on Sum of LV wall thicknesses (septum+posterior wall) (p=0.002). Borderline isolated systolic hypertension in elderly subjects was associated with increased left ventricular wall thickness (20.5 vs 19.7 mm; p=0.002) and impaired diastolic filling.