Key result
Sirt1 gene and protein expression was increased in the hearts of spontaneously hypertensive rats compared with normotensive rats and was positively related to left ventricular hypertrophy.
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Hypothesis-generating for Sirt1 in hypertensive LVH; human studies needed before clinical relevance.
Li et al. (2009) studied Hypertensive cardiovascular hypertrophy. Sirt1 expression vs. Normotensive WKY rats was evaluated on Sirt1 gene and protein expression in heart and aorta and relation to left ventricular hypertrophy. Sirt1 gene and protein expression was increased in the hearts of spontaneously hypertensive rats compared with normotensive rats and was positively related to left ventricular hypertrophy.
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