Key result
Diabetes in women links to ~22% greater LV mass and increased wall thickness.
Why the study?
Does diabetes mellitus independently alter echocardiographic parameters of cardiac structure and function in patients without prior cardiovascular disease?
Population
4,515 subjects from the original Framingham Study cohort and the Framingham Offspring Study, excluding those…
Comparison
Diabetes mellitus and glucose intolerance vs Nondiabetic subjects
Design
Cross-sectional
Authors
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Should not yet change practice in asymptomatic diabetic women; hypothesis-generating for sex-specific diabetic cardiomyopathy.
Cohort (n=4,515)
Does diabetes mellitus independently alter echocardiographic parameters of cardiac structure and function in patients without prior cardiovascular disease?
Absolute Event Rate: 100.4% vs 82.2%
p-value: p=<0.001
Diabetes mellitus is independently associated with increased left ventricular mass and wall thickness in women without prior cardiovascular disease, supporting the existence of a distinct diabetic cardiomyopathy.
Galderisi et al. (1991) conducted a cohort in Diabetes mellitus (n=4,515). Diabetes mellitus vs. Nondiabetics was evaluated on Left ventricular mass corrected for height in women (p=<0.001). Diabetes mellitus in women was independently associated with increased left ventricular mass (100.4 vs 82.2 g/m, P<0.001) and wall thickness (18.7 vs 17.1 mm, P<0.001) compared to nondiabetics.
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