Key result
Every 1% higher glycated hemoglobin was associated with a 3.0 g higher left ventricular mass (95% CI, 1.5-4.6 g), higher E/E' by 0.5, and higher global longitudinal strain by 0.3%.
Why the study?
Does dysglycemia alter cardiac structure and function in elderly individuals without prevalent heart disease?
Cross-Sectional (n=4,419)
Does dysglycemia alter cardiac structure and function in elderly individuals without prevalent heart disease?
Effect estimate: 3.0 g increase per 1% higher HbA1c (95% CI 1.5-4.6)
p-value: p=≤0.01
Worsening dysglycemia is associated with subclinical alterations in cardiac structure and function in elderly individuals without prevalent cardiovascular disease.
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Supports subclinical cardiac effects of dysglycemia in elderly without CVD; hypothesis-generating, prospective studies needed.
Skali et al. (2015) conducted a cross-sectional in Dysglycemia (n=4,419). Dysglycemia (HbA1c levels) vs. Normal glycemic status was evaluated on Left ventricular mass (3.0 g increase per 1% higher HbA1c, 95% CI 1.5-4.6, p=≤0.01). Every 1% higher glycated hemoglobin was associated with a 3.0 g higher left ventricular mass (95% CI, 1.5-4.6 g), higher E/E' by 0.5, and higher global longitudinal strain by 0.3%.
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