Key result
A combined FMD-HS-BQ vaccine elicited protective antibody titers against FMDV serotypes O, A, and Asia 1 in sheep and goats up to 90 days post-vaccination, with no significant difference compared to FMD vaccine alone.
Why the study?
Foot-and-mouth disease is subclinical in small ruminants, which may spread the disease, yet they are not currently included in vaccination coverage under India's FMD-control programme.
Does a combined vaccine (FMD, HS, BQ) produce a similar humoral immune response compared to FMD vaccine alone in sheep and goats?
Does a combined vaccine (FMD, HS, BQ) produce a similar humoral immune response compared to FMD vaccine alone in sheep and goats?
A combined FMD, HS, and BQ vaccine provides a similar protective humoral immune response up to 90 days as the FMD vaccine alone in sheep and goats, suggesting a cost-effective strategy.
Foot-and-mouth disease is subclinical in small ruminants and they may play role in spread of disease. Presently, they are not included in vaccination coverage in India under FMD-control programme. A total of 43 animals including sheep (16) and goat (27) were used for vaccination study by combined vaccine (FMD, HS and BQ) and FMD vaccine alone. Humoral immune response was evaluated by monitoring serum antibody titres against FMDV serotypes O, A and Asia 1 on 30, 60, 90 dpv. In both vaccinated groups, peak antibody titre for all 3 serotypes was obtained on 30 dpv, it remained constant up to day 60 and after that there was gradual decrease at 90 dpv. As in both groups there was no significant difference and protective titre remained upto 90 dpv, use of combined vaccine can be suggested as cost effective strategy.
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Kumar et al. (2020) studied Foot-and-mouth disease (FMD) vaccination response (n=43). Combined FMD-HS-BQ vaccine vs. FMD vaccine alone was evaluated on Serum antibody titres against FMDV serotypes O, A and Asia 1. A combined FMD-HS-BQ vaccine elicited protective antibody titers against FMDV serotypes O, A, and Asia 1 in sheep and goats up to 90 days post-vaccination, with no significant difference compared to FMD vaccine alone.
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