Key result
Human adipose-derived cells exhibit slower growth and altered metabolism compared to skin fibroblasts.
Population
Cultured cells derived from human adipose tissue (CAT cells) and cultured skin fibroblasts
Comparison
Insulin stimulation vs Cultured skin fibroblasts and unstimulated cells
Design
Preclinical
Authors
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Provides potential in vitro obesity model; leaves open in vivo or clinical translation.
Cultured cells from human adipose tissue exhibit distinct morphological and metabolic characteristics compared to skin fibroblasts, potentially offering a useful model for studying human obesity.
Dixon-Shanies et al. (1975) studied this question. Cultured cells derived from human adipose tissue (CAT cells) vs. Cultured skin fibroblasts was evaluated on Growth rate and metabolic activity. Cultured cells derived from human adipose tissue exhibited a slower growth rate and different metabolic activity compared to cultured skin fibroblasts.
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