Key result
Platelet interaction with polystyrene/poly(methyl methacrylate) demixed surfaces is driven by the entrapment and build-up of von Willebrand Factor from whole blood.
Population
Human platelets in whole blood (in vitro model)
Comparison
Polymer demixed surfaces produced by spin… vs null
Design
Preclinical
Authors
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Hypothesis-generating for polymer substrates in platelet assays; human validation required before clinical adoption.
Polymer demixed surfaces support platelet adhesion through the entrapment of autologous von Willebrand Factor, demonstrating potential utility as substrates for clinical dynamic platelet function assays.
Ward et al. (2017) studied this question. Polystyrene/Poly(methyl methacrylate) demixed surfaces was evaluated on Platelet interaction and von Willebrand Factor entrapment. Platelet interaction with polystyrene/poly(methyl methacrylate) demixed surfaces is driven by the entrapment and build-up of von Willebrand Factor from whole blood.
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