Key result
Expression of the macaque TRIM5-CypA isoform resulted in a weaker block to HIV-1 infection compared to wild-type cells (0.12% vs 0.04% infectivity, p=0.0068).
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May attenuate HIV-1 restriction; leaves open TRIM5-CypA isoform function in primate lentiviral defense.
Absolute Event Rate: 0.12% vs 0.04%
p-value: p=0.0068
Newman et al. (2008) studied HIV-1/SIV restriction (n=129). TRIM5-CypA allele (T allele) vs. Wild-type TRIM5 allele (G/G) was evaluated on Mean infectivity (% GFP-positive cells) of VSV-pseudotyped HIV-1 in PBMC (p=0.0068). Expression of the macaque TRIM5-CypA isoform resulted in a weaker block to HIV-1 infection compared to wild-type cells (0.12% vs 0.04% infectivity, p=0.0068).
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