Key result
IV 17beta-oestradiol dilates renal, iliac, and coronary circulations via nitric oxide in pigs.
Population
Pigs anaesthetized with sodium pentobarbitone
Design
Preclinical
Authors
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Does not support clinical use of oestrogen for vasodilation; leaves open translation of nitric oxide-dependent effects to human circulations.
17beta-oestradiol induces nitric oxide-dependent vasodilation in renal, iliac, and coronary circulations in an anesthetized pig model.
Vacca et al. (1999) studied Anaesthetized pigs. 17beta-oestradiol was evaluated on Regional blood flow (mesenteric, renal, iliac, and coronary). Intravenous infusion of 17beta-oestradiol dilated renal, iliac, and coronary circulations in a nitric oxide-dependent manner in anaesthetized pigs.
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