Why the study?
Does prolonged estradiol-17 beta treatment reproduce pregnancy-associated endocrine and hemodynamic alterations in nonpregnant ovariectomized ewes?
Population
Nonpregnant ovariectomized ewes (n = 5)
Comparison
Estradiol-17 beta 5 microgram/kg iv followed by… vs Baseline/control values
Design
Preclinical
Follow-up
14 days of treatment and 4 days posttreatment
Authors
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Models pregnancy-like hemodynamics with estradiol in ewes; extends mechanistic insights but leaves open human translation.
Does prolonged estradiol-17 beta treatment reproduce pregnancy-associated endocrine and hemodynamic alterations in nonpregnant ovariectomized ewes?
Chronic estradiol-17 beta infusion in nonpregnant ovariectomized ewes induces hemodynamic changes similar to pregnancy, such as decreased systemic vascular resistance and increased cardiac output.
Magness et al. (1993) studied this question.
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