Key result
Dutasteride pretreatment is linked to ~29% less surgical bleeding during open prostatectomy vs no pretreatment.
Why the study?
Does pretreatment with dutasteride reduce surgical blood loss in patients with BPH undergoing open prostatectomy?
Population
218 patients with benign prostatic hyperplasia (BPH) who underwent open prostatectomy (OP)
Comparison
Dutasteride for at least 6 weeks before open… vs Dutasteride naïve (n=172)
Design
Cohort
Follow-up
perioperative period
Authors
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May support dutasteride pretreatment to reduce bleeding; hypothesis-generating pending randomized confirmation.
Cohort (n=218)
Does pretreatment with dutasteride reduce surgical blood loss in patients with BPH undergoing open prostatectomy?
Absolute Event Rate: -1.93% vs -2.72%
p-value: p=0.01
Pretreatment with dutasteride for 6 weeks before open prostatectomy significantly reduces perioperative surgical bleeding.
Gökçe et al. (2015) conducted a cohort in Benign prostatic hyperplasia (BPH) (n=218). Dutasteride vs. Dutasteride naïve was evaluated on Surgical blood loss (estimated by hemoglobin drop and transfusion amount) (p=0.01). Pretreatment with dutasteride for at least 6 weeks before open prostatectomy significantly reduced surgical bleeding compared to no pretreatment (-1.93 g/dL vs -2.72 g/dL; p=0.01).
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