Key result
Elevated MHR predicts ISR after DES implantation in NSTE-ACS patients.
Why the study?
The predictive value of monocyte count to high-density lipoprotein cholesterol ratio (MHR) in in-stent restenosis (ISR) after drug-eluting stent (DES) implantation had not been explored.
Does elevated pre-procedural monocyte count to high-density lipoprotein cholesterol ratio (MHR) predict in-stent restenosis in NSTE-ACS patients after drug-eluting stent implantation?
Cohort (n=214)
No
Does elevated pre-procedural monocyte count to high-density lipoprotein cholesterol ratio (MHR) predict in-stent restenosis in NSTE-ACS patients after drug-eluting stent implantation?
Elevated pre-procedural monocyte count to high-density lipoprotein cholesterol ratio (MHR) is an independent predictor of in-stent restenosis in NSTE-ACS patients treated with drug-eluting stents.
Elevated MHR may identify higher restenosis risk in NSTE-ACS post-DES; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: The clinical value of monocyte count to high-density lipoprotein cholesterol ratio (MHR) in in-stent restenosis (ISR) of patients who have undergone bare metal stent implantation has been studied. However, the predictive value of MHR in ISR for patients who have undergone drug-eluting stent (DES) implantation has not been explored. METHODS: Non-ST segment elevation acute coronary syndrome (NSTE-ACS) patients who had undergone DES implantation and coronary angiography follow-up at the Beijing Shijitan Hospital, Capital Medical University, between January 1, 2008, and December 31, 2018, were retrospectively enrolled. Patients were divided into ISR and non-ISR groups depending on the follow-up coronary angiography results. Relative clinical information was recorded and analyzed. The receiver operating characteristic curve analysis was used to determine the optimum cut-off pre-procedural MHR to predict ISR. RESULTS: A total of 214 patients were enrolled in our study. The mean period between two coronary angiography procedures was 25.4±9.8 months. Percutaneous coronary intervention due to NSTE myocardial infarction, a bifurcation lesion, increased platelet count, and a high MHR were the independent risk factors in multivariate logistic regression analyses. CONCLUSION: Our results indicated that elevated MHR is an independent and useful predictor of ISR in NSTE-ACS patients who have undergone DES implantation.
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Nan et al. (2020) conducted a cohort in Non-ST segment elevation acute coronary syndrome (NSTE-ACS) with drug-eluting stent implantation (n=214). Elevated monocyte count to high-density lipoprotein cholesterol ratio (MHR) vs. Lower MHR was evaluated on In-stent restenosis (ISR). Elevated monocyte count to high-density lipoprotein cholesterol ratio (MHR) was an independent predictor of in-stent restenosis in NSTE-ACS patients after drug-eluting stent implantation.
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