Key result
Ischemia markedly increases phosphofructokinase and aldolase binding in animal hearts, likely driven by falling pH.
Population
Perfused rat and sheep hearts, and isolated myofibrils
Design
Preclinical
Follow-up
10 minutes
Authors
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No immediate clinical implications; leaves open whether ischemia-driven enzyme binding occurs in human hearts.
Ischaemia induces species-specific increases in the binding of glycolytic enzymes to cardiac myofibrils, likely driven by a fall in pH, suggesting a shift in enzyme organization to meet altered metabolic demands.
Clarke et al. (1984) studied Ischaemia. Ischaemia vs. Baseline/Normoxia was evaluated on Binding of glycolytic enzymes. Ischaemia in perfused rat and sheep hearts markedly increased the binding of phosphofructokinase and aldolase, likely driven by a fall in pH.
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