Key result
Inflow occlusion-induced ischemia in rabbits increases GSK3β transcription and lactate while lowering glycogen and pH.
Population
Adult New Zealand white rabbits
Design
Preclinical
Authors
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GSK3β may mediate glycogen depletion during ischemia in rabbits; leaves open its therapeutic targeting in veterinary models.
In a rabbit model of myocardial ischemia, increased GSK3β transcription correlates with metabolic adaptations that sustain anaerobic glucose metabolism via glycogen modulation.
Daniela Fantini Vale (2015) studied Myocardial ischemia. Inflow occlusion (IO) was evaluated on GSK3β transcription and activity, glycogen quantification, lactate levels, and pH. Inflow occlusion-induced myocardial ischemia in rabbits increased GSK3β transcription and lactate levels, and decreased glycogen content and pH.
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