Key result
Transient ischemia via brief coronary artery occlusions increased regional myocardial glycogen synthase I activity threefold during reperfusion (0.58 vs. 0.18 mumol/g/min, P<0.01).
Population
Intact, anesthetized rats (including diabetic rats)
Comparison
Sequential 2-min periods of left coronary artery… vs Posterior region of the left ventricle and…
Design
Preclinical
Authors
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May represent a metabolic feature of ischemic preconditioning; hypothesis-generating and should not yet change clinical practice.
Absolute Event Rate: 0.58% vs 0.18%
p-value: p=< 0.01
Transient ischemia induces a glucose 6-phosphate-mediated increase in glycogen synthase phosphatase activity, leading to glycogen synthesis, which may be a feature of ischemic preconditioning.
McNulty et al. (1995) studied Transient ischemia. Brief coronary artery occlusions vs. Posterior region (non-ischemic) was evaluated on Activity of glycogen synthase I form during reperfusion (p=< 0.01). Transient ischemia via brief coronary artery occlusions increased regional myocardial glycogen synthase I activity threefold during reperfusion (0.58 vs. 0.18 mumol/g/min, P<0.01).
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