Key result
Cloned human endothelin ETA receptor gene shares ~94% sequence identity with the bovine receptor.
The study successfully cloned the human endothelin ETA receptor and mapped its gene to chromosome 4.
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Enables targeted human ETA receptor studies; leaves open therapeutic relevance in cardiovascular disease.
A cDNA clone encoding a human endothelin receptor was isolated from a placenta cDNA library. The deduced amino acid sequence of the clone is 94% identical to the bovine endothelin ETA receptor and represents the human homologue. The human endothelin ETA receptor gene was localized to chromosome 4 by analysis of its segregation pattern in rodent-human hybrids.
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Cyr et al. (1991) studied this question. The human endothelin ETA receptor gene was cloned, sharing 94% amino acid sequence identity with the bovine receptor, and localized to chromosome 4.
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