Key result
Pericardial fluid antigen and PCR testing diagnoses pneumococcal pericarditis in two culture-negative patients.
Why the study?
Does antigen testing and PCR of pericardial fluid improve the diagnosis of pneumococcal pericarditis in culture-negative patients?
Population
2 patients with pneumococcal pericarditis preceded by community-acquired pneumonia
Comparison
Antigen testing and polymerase chain reaction of… vs Culture (which was negative)
Design
Case_series
Authors
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Hypothesis-generating for adjunctive pericardial fluid testing in culture-negative cases; prospective validation needed before adoption.
Case Report (n=2)
Does antigen testing and PCR of pericardial fluid improve the diagnosis of pneumococcal pericarditis in culture-negative patients?
PCR and antigen testing of pericardial fluid can successfully diagnose pneumococcal pericarditis when traditional cultures are negative, particularly in patients with prior antibiotic exposure.
Inkster et al. (2010) conducted a case report in Pneumococcal pericarditis (n=2). Antigen testing and polymerase chain reaction (PCR) of pericardial fluid was evaluated on Diagnosis of pneumococcal pericarditis. Antigen testing and polymerase chain reaction (PCR) of pericardial fluid successfully diagnosed pneumococcal pericarditis in two culture-negative patients with a history of prior antibiotics.
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